One of the most popular comedians in Tamil cinema, Senthil is known for his funny roles with fellow comedian Goundamani. Among several popular scenes of the Senthil - Goundamani duo, their comedy scene from the movie Karagattakaran (1989) gained huge popularity. Senthil gained appreciation for his comic timing in blockbuster hit movies like Hindustani (1996), Muthu (1995), Jeans (1998) and Padaiyappa (1999). His other significant movies include Billa, Aval Varuvala, Arunachalam, Jayam, Aayirathil Oruvan, and Kallappadam. His 2017 venture includes the action thriller film Thaana Serndha Kootam, under the direction of Vignesh Shivan, starring Suriya and Keerthy Suresh in the lead roles.