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Rachel Anne Griffiths AM (born in 1968) is an Australian actress. Raised primarily in Melbourne, she began her acting career appearing on the Australian series Secrets before being cast in a supporting role in the comedy Muriel's Wedding (1994), which earned her an AACTA Award for Best Actress in a Supporting Role. In 1997, she was the lead in Nadia Tass's drama Amy. She had a role opposite Julia Roberts in the American romantic comedy My Best Friend's Wedding (1997), followed by her portrayal of Hilary du Pré in Hilary and Jackie (1998), for which she received a nomination for the Academy Award for Best Supporting Actress

From 2001 to 2005, Griffiths portrayed masseuse Brenda Chenowith in the HBO series Six Feet Under, for which she earned a Golden Globe Award for Best Actress in 2002 and two Primetime Emmy Award nominations. She subsequently appeared on television as Sarah Walker Laurent on the ABC drama series Brothers & Sisters from 2006 to 2011, for which she was nominated for two additional Primetime Emmy Awards.

She has also had roles in the films Blow (2001), portraying the mother of George Jung; the historical drama Ned Kelly (2003); Step Up (2006), and the Julian Assange television biopic Underground: The Julian Assange Story (2012). In 2016, she appeared in a supporting role in Mel Gibson's biographical war drama Hacksaw Ridge, and in the docudrama miniseries When We Rise, written by Dustin Lance Black.

Onstage, Griffiths appeared in a Melbourne-based production of Proof in 2002, which earned her a Helpmann Award, and later made her Broadway debut in a 2011 critically acclaimed production of Other Desert Cities. In addition to acting, she made her directorial debut with the short film Tulip in 1998, and directed several episodes of the Australian television series Nowhere Boys in 2015.