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Sean Penn
Naomi Watts
Benicio del Toro
Charlotte Gainsbourg
Melissa Leo
Danny Huston
John Rubinstein
Clea DuVall
Eddie Marsan
Watts and Del Toro were nominated for Best Actress and Best Supporting Actor at the 76th Academy Awards. The title refers to an experiment in 1907 which attempted to show scientific proof of the existence of the soul by recording a loss of body weight (said to represent the departure of the soul) immediately following death. Referred to as the 21 grams experiment as one subject lost "three-fourths of an ounce" (21.3 grams), the experiment is regarded by the scientific community as flawed and unreliable, though it has been credited with popularizing the concept that the soul weighs 21 grams.
