When an interdimensional rupture unravels reality, an unlikely hero must channel her newfound powers to fight bizarre and bewildering dangers from the multiverse as the fate of the world hangs in the balance.
Evelyn Wang is a Chinese-American immigrant who runs a struggling laundromat with her husband, Waymond. Evelyn's demanding father, Gong Gong, has just arrived from Hong Kong, and the laundromat is being audited by the IRS. Additionally, Waymond is trying to give Evelyn divorce papers; and Evelyn's daughter, Joy, has been trying to get her mother to introduce her girlfriend, Becky, to Gong Gong. When the opportunity arises, Evelyn interjects and introduces Becky as Joy's friend.
While at the IRS building with Gong Gong and Waymond for a meeting with IRS inspector Deirdre, Waymond's body is briefly taken over by Alpha Waymond, a version of Waymond from the "Alphaverse", who gives Evelyn instructions to meet him in another universe while keeping her body in the IRS building. Alpha Waymond informs Evelyn that many parallel universes exist, with her existing with a different life path in each one, and that he needs her to help fight a darkness that is spreading throughout the multiverse.