Guddu Ki Gun is the tale of Govardhan aka Guddu (Kunal Khemu), a Bihari settled in Kolkata. He is a door-to-door salesman for washing powder, whose sales pitch is "Ek washing powder ke saath Guddu free" (With one washing powder, you get Guddu for free). While sharing a room with his close friend Ladoo (Sumeet Vyas), Guddu becomes a womanizer and leads an amorous lifestyle in Kolkata. His troubles begin when he ditches one of his girlfriends, Bholi (Aparna Sharma). Furious at Guddu for forsaking his granddaughter, Bholi's grandfather, who is a magician, casts a black magic spell on him, causing his penis to turn golden. The only way Guddu can get rid of the curse is to find true love and stay faithful to her.