The series delves into the lives of newly appointed resident doctors, surgeons, nurses, and terminally ill patients at the Elizabeth Blackwell Medical Centre in Mumbai. At the centre of it all are two lead characters—resident doctor Nitya Vasu (Harleen Sethi), who has joined with a motive for revenge, defined in the opening episode, and neurosurgeon Dr Ishaan Ahuja (Sharad Kelkar), whom Nitya believes is responsible for her brother Dhawal’s (Aamir Ali) botched surgery that left him with permanent damage.