Shakti Sharma is a kind woman who aspires to be a doctor. After losing her parents, she lives with her uncle, aunt and cousin in Varanasi. Shiv Kashyap is a doctor, who has a hurting past and is unable to heal. The series follows Shiv and Shakti's story, how they cross path and how Shakti becomes Shiv's strength.
Shiv and Shakti becomes friends after frequently meeting each other. Shiv has a tragic past which causes his hand to shiver while doing any operation. Shakti wants to become a doctor and Shiv helps him get admitted to the college which belonged to his grandfather Ramprasad Kashyap. Mandira, Shiv's evil aunt plots against Shiv and Shakti as because of their friendship her plans of destroying Shiv and Shakti's career backfires. Shiv and Shakti falls for each other while saving Rimjhim from a fraud guy. Shiv and Shakti and Keertan and Rimjhim finally marry. Mandira brings out Shiv's past in front of Shakti and creates misunderstandings between them.
Initially, Shakti was angry because Shiv has hidden the truth. Shiv loses his control and wreaks havoc. But lately Shakti realises Mandira's conspiracy and tries to win Shiv back. Actually Shiv was first married to Gauri but was killed by Mandira after her real intentions revealed in front of her. But she made it look like it happened because of Gayatri (Shiv's mother) and made Shiv felt guilty. They had a son Kartik whom they sent to hostel. In present Shakti tries to win over Kartik and then Shiv. She continues her studies and also bonds with Kartik slowly tries to win over Shiv's heart. Shakti faces various challenges led by Mandira. She gives fake medicine to Shiv in order to keep him unwell and loose his control over his anger in front of Shakti. But Shakti controls him and later takes the responsibility of Shiv's medicine.
Keertan tortures Rimjhim. Love blossoms between Koyal and Dharam. Shiv realises that he misunderstood Shakti and decides to confess her. He came to take blessings from Gayatri but she is murdered by Mandira. Shiv was framed for the murder. Shiv pretends to be mentally unstable. Shakti tries to save him from the Police. Soon, Shiv and Shakti team up against Mandira and Mandira was soon exposed by them in front of the family. Mandira is finally imprisoned for her crimes.
Shiv, Shakti and Kartik are living happily with each other. With a supernatural turn Bhagwati learns from Ramkishore about an auspicious day when Moon and Sun would be seen together. Bhagwati fears about a secret which she hid from everyone. 25 years ago Shiv was a child and visited a village called Shivpur, where at the same day he saw a Naag and Naagin consummating he mistakenly kills a Naag Kundan (Mohini's lover) mistakenly who wanted to kill him. Mohini Kills Shiv in revenge. Bhagwati runs away with a dead Shiv and took help from a tantrik Baba. He revives Shiv by killing Kundan. Baba captives Mohini inside the earth putting a Trishula. It is estimated that if Shiv or any of Shiv's successor carrying Shiv's bloodline ever comes to Shivpur and takes off the Trishula then Mohini's curse will end and she will be freed. In present Shiv with Shakti and Kartik reaches Shivpur. Kartik picks off the Trishula and Mohini is freed. Disguising as a villager Mohini takes lift from Shiv and reaches Shiv's home. On the other hand, Koyal marries Dharam. Koyal faces difficulties in adjusting with the Sharma's.
Mohini kills Bhagwati, who had learned her real identity. Shakti suspects Mohini. She creates illusions and tries to prove Shakti mentally unstable.
