Set in Lucknow, Uttar Pradesh, the show revolves around Mankameshwar "Manu" Maurya and his colourful family. Manu is honest, sincere, hardworking and noble person and is a believer in his grandmother's philosophy: "If you haven't done anything wrong to anyone, then nothing wrong would happen to you either."
Manu marries Shweta, as arranged by his family. The festive atmosphere turns sour as Shweta elopes soon after the wedding, leaving behind a letter in which she falsely accuses the Maurya family of asking for a dowry. (Shweta is involved in an affair with her boyfriend). A police inspector bribed by Shweta arrests Manu. After Manu's innocence is proven and he is released, his manager fires him from his job. Dejected but still hopeful, Manu decides to re-open 'Jai Mataji Tenthouse', which was owned by his grandfather and closed abruptly after his death.