The story of the first season is set during the 2008 Mumbai attacks, it follows the staff of Bombay General Hospital and their travails during the fateful night of 26 November 2008. It also shows incidents happening at the Taj Mahal Palace Hotel and how a journalist tries to report these incidents.
The story of the second season takes place six months after the first season, and is set against the backdrop of Mumbai flooding (similar to the Maharashtra floods of 2005) and focuses on the efforts of the medical staff to save the lives of numerous people both in the city and the ER.