The Arora sisters, Preeta and Srishti, move to Mumbai to fulfill their father’s dying wish of reuniting with their mother, Sarla. Preeta becomes a physiotherapist for Bani Luthra, the matriarch of the Luthra family. While the elder grandson, Rishabh, shares a cordial bond with her, the younger one, Karan, a cricket star, has a strained relationship with her. Preeta and Karan slowly develop a friendship that turns into love, though neither confesses their feelings.
Rishabh is set to marry Sherlyn, but Preeta and Karan discover that Sherlyn is having an affair with Preeta's fiancé, Prithvi. Despite their attempts to stop the wedding, Sherlyn manipulates the situation, and Karan, influenced by misunderstandings, starts hating Preeta. On the day of Preeta’s wedding to Prithvi, Karan takes his place, marrying her out of spite but soon abandoning her. Kareena arranges for Karan to marry Mahira, his obsessive childhood friend. Preeta then replaces Mahira and marries Karan. Despite their reconciliation, Karan and Preeta face more obstacles as Sherlyn and Prithvi continue to scheme against them.
Three months later, Preeta and Karan adopt a child, Pihu. Sonakshi, Karan’s college friend, tries to separate them due to her obsession with Karan. Sonakshi arranges for a goon to cause an accident that results in Pihu’s death. Preeta is blamed for the accident and removed from the Luthra house, while Karan expels Sonakshi for coercing him into marrying her.
Two years later, Preeta returns to Mumbai from her hometown. She meets Mahesh, who is now mentally unstable after being tortured by Prithvi. She learns that Prithvi has taken control of the Luthra business and is exploiting the family. With Mahesh’s will, Preeta re-enters the Luthra mansion and exposes Prithvi’s schemes. She helps Rishabh return from Dubai, where he had been trapped by Prithvi, and they both expose Sherlyn and Prithvi. Sherlyn and Natasha try to convince Karan that Preeta and Rishabh are having an affair. Karan is manipulated into believing this, and he is later pushed off a dam by Natasha and Roxy. He is presumed dead. Preeta, who is pregnant with Karan's child, marries Rishabh for the child’s legitimacy. Preeta gives birth to a daughter, Kavya.
Five years later, Karan is revealed to have survived the accident but suffered memory loss and undergone plastic surgery. He returns as Arjun Suryavanshi and is engaged to Nidhi Hinduja, who saved him. As Arjun, Karan tries to destroy Preeta and Rishabh, believing they pushed him off the dam. Eventually, after learning Karan's true identity, Preeta and Rishabh prove their innocence through CCTV footage. Karan regains his memory and reconciles with Preeta. He severs ties with Nidhi. After a few months, Karan and Preeta have fraternal twin sons, Rudraksh and Shaurya. Nidhi's sister, Anjali, who is obsessed with Karan, kidnaps Rudraksh. However, after a series of events, she dies in a confrontation. Preeta is once again blamed for the chaos and leaves the family, but she saves Rudraksh. It is presumed by the Luthras that Preeta and Rudraksh have died.
Twenty years later, Preeta and Srishti have relocated, and Srishti has raised Preeta’s son, Rudraksh, whom she renamed Rajveer. Preeta, who lost her memories after the accident, suffers from panic attacks. Rajveer, now grown up, learns about his true parentage and returns to Mumbai with a determination to reclaim Preeta’s honor. Meanwhile, Rajveer gets a job at Karan’s company, and Shaurya grows insecure about Rajveer and plots against him. Rajveer and Palki fall in love, while Nidhi and Shaurya continue to plot against Rajveer and Preeta. The Luthra family slowly begins to accept Preeta again. Kavya's fiancé, Varun, is revealed to be Prithvi and Sherlyn's son, Shelly, who came to take revenge. The relationship is called off. Rajveer is appointed CEO of Luthra Industries. Soon, Preeta realizes Shaurya's scheming, and a huge confrontation ensues, with Nidhi blaming Shaurya's actions on Rajveer. In a fit of rage, Rakhi and Mahesh end up revealing Rajveer's true identity in front of Preeta, triggering her memory. She collapses into a coma, and the family prays for her recovery.
