Radhe Lal Shukla lives in Kanpur, Uttar Pradesh and belongs to a rich yet illiterate family. Humiliated for his illiteracy, his dominating and arrogant non-biological father Gajodhar chooses district-topper Krishna Dubey as his bride from the neighboring town of Malihabad.
Intelligent and ambitious, Krishna assists her father at his medical clinic. Her mother had died of cervical cancer. Krishna dreams of studying medicine in London and becoming a doctor, but still marries Radhe for her father's reputation. She is humiliated by the Shukla family members who resent her for independent thoughts and modern views.
However, Radhe supports Krishna. Gradually, she falls in love with him and brings some positive changes into the Shukla household. It is revealed that Radhe is Gajodhar's brother Lambodar's son. Lambodar had murdered his wife Vrinda (Radhe's mother, who tried to save Gajodhar's wife Raima from Lambodar's unwanted sexual advances).
Lambodar is imprisoned. Radhe and Krishna leave for London. In medical school, Krishna is punished by stern and arrogant NRI professor Dr. Veer Sahay, a famous clinical cardiologist whose native city is Unnao. Veer is expelled from his job for racist behaviour. His car hits Radhe, who dies in the accident.
The Shuklas promptly blame Krishna for Radhe's death and mistreat her. Emotionally broken, Krishna is forced to stay with the Shuklas who had recently opened a special hospital named Radhe Krishna Hospital where she must now work. Meanwhile, Lambodar tries to escape from prison and is hospitalised.
Veer returns to India. His past turns out to be connected to Shuklas. His father Sharad worked for Gajodhar who refused to lend him money for an important surgery which eventually led to Sharad's death. Veer harbours a deep grudge against Shuklas. He and Krishna are forced to run the Radhe Krishna Hospital, slowly fall in love and marry.
Veer buys the Radhe Krishna Hospital at an auction and gifts it to Krishna. Gajodhar manipulates Krishna that Veer killed Radhe and was faking his love for her. Veer gets ten years imprisonment for Radhe's murder. Heartbroken, Krishna returns the hospital to Gajodhar and leaves for London to complete medical school.
Five years later
Krishna is now an honest and sincere professional doctor working at the Life Care Hospital. Gajodhar asks her to work in his hospital for his business growth, but she rejects the offer. Veer escapes from prison to meet Krishna and pleads his innocence but is soon captured and sent back to prison.
A mysterious man convinces an emotional Raima and her son Gajanan that he is Radhe. Veer's mother Sunaina wants Gajodhar to bail Veer out as "Radhe" has now returned. Veer is bailed and investigates the actual identity of new Radhe. Veer and Krishna discover that the new Radhe is actually Mohan who is defrauding the family.
Soon, the Shuklas realise that they were being duped by Mohan. They are grateful to Veer and Krishna for exposing him. Veer and Krishna reject an appointment letter from the London Royal Hospital to stay back in Kanpur with the Shukla family who give them their blessings.
