Mauli Srivastav and Nandini Verma are best friends who grew up together. Nandini chooses Rajdeep Thakur over Mauli's friendship despite her of warning Nandini of his bad character which leads to a fallout between the two and they part ways.
Mauli, who is now a gynaecologist is married to Dr. Kunal Malhotra who is a pediatrician. Married to Rajdeep, Nandini is a victim of domestic violence. An ambitious businessman and a dominating husband, Rajdeep often abuses Nandini, both physically and mentally.
Kunal sees Nandini at a medical conference and saves her from a major accident. He discovers she is the friend Mauli reminisces about. He discusses it with Mauli. She meets Nandini after seven years. Nandini informs Mauli of her pregnancy. Rajdeep beats Nandini upon hearing about her pregnancy and leaves her on a road. Kunal finds her and takes her to the hospital. Nandini miscarries.
With the support of Mauli & Kunal, she gets Rajdeep arrested on domestic abuse charges and begins to live in Mauli & Kunal's home. He starts falling for her. He reminds himself about Mauli but is unable to stop thinking about Nandini. Slowly, she begins to feel the same for Kunal and decides to leave town due to her inability to control her romantic feelings for him.
When Kunal learns this, he stops her and confesses his own feelings. Nandini and Kunal start to love each other secretly. Mauli is heartbroken upon knowing this and wants to move out his house. Kunal's mother stops her from leaving and forces Kunal to leave instead as he's the one who's wrong. Kunal accepts his mistake and gets out of house. Mauli files for a divorce. After Kunal and Mauli part ways, Kunal and Nandini plan to get married. Mauli finds out that she is pregnant. Kunal discovers this, but accuses her of false pregnancy after a misunderstanding. He marries Nandini and they move out while Mauli decides to go on by herself.
After a few years, Mauli lives with her daughter, Mishti and best friend Ishaan Khanna. Kunal returns from London with his and Nandini's daughter Pari. He is unaware that Mishti is his daughter. Mishti and Pari become best friends, unaware they are half-sisters. Kunal and Mauli come face to face. She learns that Nandini died due to cancer. She is deeply heartbroken and begins to take care of Pari as her own.
Kunal discovers that Mishti is his daughter. However, Mishti also learns that Kunal is her father and becomes bitter towards him and Pari for having caused her mother's heartbreak. Mauli finally forgives Nandini and promises to love Pari like her own daughter. Ishaan proposes to Mauli. Kunal loses his memory in an accident, only remembering Mauli. She stays with him. Kunal after having visions of past finally regains his memory and meets Pari and Mishti. Later Mauli realizes her love for Ishaan and chooses him over Kunal. They both get married and they soon have a son named Ansh. Mishti forgives Kunal but chooses Ishaan as her father, and he adopts her.
Mishti, Pari and Ansh grow up. Mauli, Kunal and Ishaan are dead. Mishti is a perfectionist who believes in love and commitment, about to get engaged to her boyfriend, Veer. Pari is commitment phobic and easy going; her childhood friend Arnav loves her but she doesn't love him. Mishti and Pari run an event-management company.
Pari gets fascinated by Veer's friend, Ruhaan; who is attracted to Mishti. He develops a conflicting relation with Mishti and an easy going bond of friendship with Pari.
Mishti and Veer get engaged. Ruhaan tries to ignore his feelings for her. Mishti is nervous sensing how she feels around Ruhaan and tries to push away her love.
Pari starts falling for Ruhaan. Arnav is heartbroken. Eventually, Mishti accepts her feelings for Ruhaan. They confess their love to each other; she breaks up with Veer, who informs Pari about Mishti and Ruhaan's relationship hoping to cause problems between them. Upon knowing Pari's feelings for Ruhaan, Mishti decides to sacrifice her love.
She denies having feelings for Ruhaan by faking to get back with Veer. Pari proposes Ruhaan but is heartbroken when he rejects her. Ruhaan questions Mishti's sacrifice. She is adamant. Later after many discussion mishti-veer and pari-ruhaan's marriage is fixed .on the wedding day, Mishti faints and is diagnosed with a lupus. Pari discovers Mishti and Ruhaan's love for each other, and donates her kidney to save Mishti.
Mishti and Ruhaan get married and move into a new house in same apartment. Pari finally accepts Arnav’s love, hinting that she might develop feelings for him too. Mishti, Pari, Ruhaan, Ansh and Arnav celebrate together with Kunal's mother, Radhika.
